Running head: CURRENT MANAGEMENT AND TREATMENT OF COVID19 1

CURRENT MANAGEMENT AND TREATMENT OF COVID19 37

CURRENT BEST PRACTICES FOR THE MANAGEMENT AND TREATMENT OF COVID-19: A CASE STUDY

HCIN 699-51- B-2020/Fall

Applied Project in Healthcare Infor

Professor Chaza Abdul and Professor Glenn Mitchell

Prepared by:

Name: Wassim Alzayed

Student ID: 264319

Harrisburg University

12/06/20

TABLE OF CONTENTS

ABSTRACT 5 INTRODUCTION 6 Background Information 6 Problem Statement 9 Purpose Statement 10 Research questions 10 LITERATURE REVIEW 11 Overview of the study 11 Literature Review 11 Virology 12 Therapeutics and treatment options 12 Convalescent plasma or blood plasma therapy 17 RESEARCH METHODOLOGY 20 Research Design Overview 20 Inclusion criteria 20 Data collection method 21 Data analysis 21 RESULTS 23 Discussion 25 Limitations 26 Conclusion 26 REFERENCES 29

List of figures

Figure 1: Simplified Representation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Lifecycle and Potential Drug Targets ( Sanders et al., 2020 ) 10

List of Tables

Table 1: Summary of Pharmacology for Select Proposed COVID-19 Treatments ( Sanders et al., 2020) 12

Table 2: Table for the vaccines platform, attributes and status of vaccines attributes.( Lurie et al. 2020 ) 16

ABSTRACT
In December 2019, The severe Acute Respiratory Syndrome Coronavirus 2 ( SARS-CoV-2) virus was originated in Wuhan City of Hubei Province in People Republic of China. The viral disease caused by ( SARS-CoV-2) virus is named Corona Virus disease 2019 ( COVID-19 ). Currently the virus invaded 213 countries and territories worldwide, with 17.3 million confirmed cases of COVID – 19 and around 650,000 death globally (WHO, 2020, P.1). As of today, Based on John Hopkin, the United stated of America is considered today the most reported COVID – 19 confirmed cases of 4.6 million people and the highest mortality rate of over 192,000 death cases.(CDC, 2020, John Hopkin University, 2020).Some of these medication where granted an emergency dispensing authority to assure optimal safety and efficiency treatment in the life threatening cases of Corona Virus disease 2019 ( COVID-19 ). Therefore we shall summarize the currently used and the potential promising agents to combat the ( SARS-CoV-2) virus. In addition, we shall highlight the current status and stages in the development of the vaccines as well.

Keywords: Severe Acute Respiratory Syndrome Coronavirus 2 Virus (SARS-CoV-2), Corona Virus disease 2019 (COVID-19 ), World Health Organization (WHO), Vaccine.

INTRODUCTION
Background Information
The new strain of corona virus SARS-CoV-2 was recognized as the causative agent of the pandemic COVID-19. The SARS-CoV-2 was originated in the city of Wuhan in Hubei providence in the Rep