spatial orientation scores were significantly better for participants after their low-aspartame intake period than after their high intake period (Table 2). Two participants had clinically significant cognitive impairment after consuming high-aspartame diets. . . . Participants were significantly more depressed after they consumed the high-aspartame diet compared to when they consumed the low-aspartame diet (Table 2). . . . Only one participant reported a headache; no difference in headache incidence between high- and low-aspartame intake periods could be established’ (Lindseth et al.