Characterisation of the binding modes of inhibitors and cofactors in the KMO enzymeStrategic AlignmentBriefly outline how the research proposal is aligned to the selected Research Council Objectives [up to 1000 chars inc. spaces].This research aligns with the strategic priorities of the Medical Research Council (MRC) as it aims to investigate the gaps in knowledge and infrastructure needs to deliver new insights and benefits to human health. As stated in their strategic plan one research priority is living a long and healthy lifestyle and in doing this is understanding molecular datasets and diseases by using biological indicators and being able to target treatments. The Molecular, Cellular and Medicine Board (MCMB) is keen to understand dynamic biological systems and this research proposal requires understanding the dynamics of the KMO enzyme and application of this allows development of inhibitors to match the drug site and gaining an understanding of their mechanism of action. This research uses analytical tools and systems approaches to understand complex and dynamic biology different scales. These approaches will be used to develop cell therapies and cell engineering systems biology for drug target discovery and development. This will help us understand the mechanisms of the enzyme and allow us to develop new drugs that target the enzyme.
