Research Article The Difference of the Polymorphism of RS4360791 Loci of ALOX5AP Gene between Cerebral Infarction of the Uygur andHan Ethnic Groups InXinjiang1. AbstractObjective?To explore the difference of the polymorphism of RS4360791 loci of ALOX5AP gene between cerebral infarction of the Uygur and Han ethnic groups in Xinjiang Province, China.Methods?This is a case-control study. The polymorphism of the genotype of RS4360791 loci of ALOX5AP gene and the frequency of its allele were tested using polymerase chain reaction and DNA sequencing. And the association between different genotypes and the risks of cerebral infarction of Uygur and Han ethnic groups were analyzed using Pearson chi square test and multivariate logistic regression model.Results: There was no significant difference in the ALOX5AP gene rs4360791 between the Uygur and the Han (P>0.05).Conclusion: In this study, the ALOX5AP gene RS4360791 polymorphisms in Xinjiang Uygur and Han nationality cerebral infarction were studied: this gene positions between cerebral infarction in Han and Uyghur The point genotype and gene frequency were not statistically significant (P>0.05).Key words: 5-lipoxygenase activator protein; Ischemic stroke; Gene; Atherosclerosis2. IntroductionIschemic stroke is a complicated disease related with different factors and its prevalence increases with risk factors like hypertension, diabetes and smoking. A considerable number of ischemic stroke attacks are caused by vessel stenosis and emboli derived from unstable plaques. Arterial atherosclerosis is one the major pathology processes of ischemic stroke and inflammatory factors are key elements to trigger atherosclerosis. Analysis of inflammatory factors can help understand the risk factors of ischemic stroke, assisting treatment and second prevention of stroke and lowering the burden of families and societies.Arterial atherosclerosis is a chronic inflammatory disease, contributing to cerebrovascular diseases [1-2]. Leukotriene, the product of the 5- lipoxygenase activator protein (5-LAP) and 5-lipoxygenase(5-LO) pathway, accelerates the process of atherosclerosis. It promotes lipid streak formation, stable/unstable plaque pathological process and plaque rupture, resulting in cerebrovascular diseases.ALOX5AP related mutation may be associated with excretion of substances like leukotriene, leading to arterial atherosclerosis formation, and subsequently vessel stenosis, and plaque rupture as well as the final the ischemic stroke caused by arterial vessel occlusion [3]. The aim of this study is to explore the relationship between the polymorphism RS4360791 loci of ALOX5AP gene and artery atherosclerosis
